Lionel Messi was subbed off in the 37th minute of Inter Miami's MLS contest against Toronto FC on Wednesday with an apparent right leg ailment.

"During a brief moment, Messi stretched his right leg out during the 34th minute of the match.

"Messi was bent over and just tending to his leg around the midfield area.

"Messi seemed to be favoring his right leg, around the calf area, shortly after he charged to the box that ended when Messi was defended too wide.

"Two minutes later, Messi was heading to the sidelines."

Messi was playing in his first match since Sept. 7, when he led Argentina over Ecuador 1-0 in a 2026 World Cup qualifying contest.

Messi has played 12 matches with Inter Miami since July 21, when he made his debut for the team. Inter Miami, which was last in the MLS table when Messi joined the team, hasn't lost a game in which the seven-time Ballon d'Or winner has played.

On Wednesday, Messi was quite active, taking three shots (one on goal) within a six-minute period in the first half. None found the net, but Inter Miami did later when Facundo Farías scored to give his team a 1-0 lead right before halftime.

As for Messi, he gave the captain's armband to DeAndre Yedlin before exiting. Robert Taylor replaced Messi in the lineup.

Three minutes prior to Messi's exit, Jordi Alba also left the game with an undisclosed injury. Inter Miami head coach Tata Martino provided an update at halftime.

Favian Renkel @FavianRenkel

Tata Martino On Apple TV on Lionel Messi and Jordi Alba<br><br>"They had to leave the game, we will evaluate them during the week."<br><br>Translated from Spanish <br><br>Messi and Alba were not supposed to come off in the first half per Tata. <a href="">#MLS</a> <a href="">#MLSSeasonPass</a> <a href="">#InterMiamiCF</a> <a href="">#Intermiami</a>

Inter Miami's next match is an MLS contest on Sunday against Orlando City SC. They then play the Houston Dynamo next Wednesday in the U.S. Open Cup final.