Juggling a busy career and motherhood is challenging enough, but add infertility, miscarriage, and breast cancer to the mix and the difficulty escalates astronomically.

That's what E! News co-host Giuliana Rancic has endured over the last few years, and she and her entrepreneur (and Kitchen Casino host) husband have done it quite publicly on their E! series Giuliana & Bill, now in its seventh season. This time around, the parents of Duke, 17 months, are hoping to have another baby, and here she opens up about that, her marriage, and living life on camera.

YourTango: You're trying to have a second child.
Giuliana Rancic: Yes. Duke was a blessing. We tried for years to have Duke. It was on the third IVF cycle that I found that I had breast cancer, which was obviously a very scary time. So when Duke finally came along a year after my diagnosis, through a surrogate, it was an incredible day. We definitely don't take Duke or having children for granted. We realize what an incredible gift it is. We asked our surrogate in the first episode if she would do it again, and she did agree to do it again. But just like everything else in our lives, there's ups and downs this season, even with the whole trying to have a second baby. It's a bit of a roller coaster ride of emotions this season, and so episode 10, the finale, I think will shock a lot of people because it's very different from episode 1. 

YourTango: How hard is it to have really deeply personal conversations so publicly, having your private life out there for everyone to discuss?                          
Giuliana Rancic: It's gotten easier now that we've done seven seasons. We don't feel the cameras as much as we used to, and we're okay with it, because there has been a lot of positive feedback. We're okay just opening up our lives, and we feel like as long as people can relate to us and they enjoy watching us, maybe they get a little takeaway from our show, we're really happy to put it out there. We just feel at the end of the day, we have this unbelievable platform — Bill with the shows he does and me with the shows I do. It's like, why not try to give back a little bit, too, and actually help people out in the process and help people feel less alone? 
So we just feel it's a nice thing and it also makes us feel great when people say that they learned from our show. 

YourTango: What's Duke like?
Giuliana Rancic: A huge flirt. He's so cute. Very energetic. Loves running, sprints everywhere. He's the best.

YourTango: Would you like to have a girl?
Giuliana Rancic: I've always wanted a girl, but then I think a boy would be nice because he and Duke would have each other. But I don't know how many chances we're gonna get, and if this is the last time, I'd love a girl. One of each would be nice.

YourTango: Was it love at first sight when you met Bill?
Giuliana Rancic: It was for me. I watched him on The Apprentice and I thought he was foxy. I interviewed him for E! and I was in love with him from the beginning. I don't know if it was the same for him.

YourTango: What's the secret to a solid and happy relationship?
Giuliana Rancic: You have to put the other person first. If I put my husband first, we both win.

YourTango: How do you resolve disagreements?
Giuliana Rancic: We never let it get very far. We just say to each other, "We're together the rest of our lives. I'm not going anywhere, you're not going anywhere so let's work it out." If you realize you're in it for the long haul, there's security and comfort in that, and you're able to brush it aside.

YourTango: What would you tell your younger self that you know now about love and relationships?
Giuliana Rancic: Even when you think you're dating the perfect guy, think to yourself, "Would he make a good dad and a good husband?" That's very important because I remember I dated a guy for a couple of years and I thought, "I don't know if he'd make a great dad or husband, and make the kids the priority." I knew that Bill would.

YourTango: When was the last time you surprised him with something romantic?
Giuliana Rancic: I surprised him with a trip to Mexico, rented a house there.

YourTango: What else do you do for each other to show your love?
Giuliana Rancic: We always check in with each other a couple of times a week; the idea is to get anything that's brewing off your chest, but it's not just about airing the bad stuff and what's bothering you but also what's making you happy. That way the person can do more of that and that's important.

YourTango: What celeb couple would you like to double date with?
Giuliana Rancic: Brad and Angelina. She's incredible with all the good work that she does around the world.